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Undifferentiated Presentations — Generalized weakness

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Case 1 of 3Undifferentiated PresentationsGeneralized weakness

A 70-year-old woman presents to the emergency department with 1 week of generalized weakness and painful leg cramps. She has had no vomiting, diarrhea, or laxative use. She has had hypertension for 5 years and takes hydrochlorothiazide 25 mg PO daily and no other medications. She has no known drug allergies. On examination she is alert, with symmetric reduced proximal muscle strength and normal reflexes. Sodium is 134 mmol/L (135-145), potassium 2.8 mmol/L (3.5-5.0), magnesium 0.6 mmol/L (0.7-1.0), and creatinine 78 umol/L (45-90). ECG shows sinus rhythm with T-wave flattening and prominent U waves and no arrhythmia. She is able to swallow tablets.

Heart rate78/min
Respiratory rate16/min
Temperature36.8 °C
O2 saturation98%, room air
Blood pressure138/82 mm Hg

Question 1 of 9

Which of the following are the most appropriate initial treatments?

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