Case 1 of 9Pregnancy and Reproductive HealthPrenatal care (e.g., folic acid use)
A 27-year-old woman presents to her family physician for a preconception visit. She has juvenile myoclonic epilepsy and has been seizure-free for 2 years on valproic acid 1000 mg/day. She also takes minocycline 100 mg PO BID for moderate inflammatory acne and uses condoms for contraception. She and her partner plan to conceive in the next 6 to 12 months. Her neurologic and general examinations are normal, and she has no known drug allergies.
| Heart rate | 72/min |
| Respiratory rate | 14/min |
| Temperature | 36.8 °C |
| O2 saturation | 99%, room air |
| Blood pressure | 112/70 mm Hg |
Question 1 of 27
Which of the following are the most appropriate changes to her medications before she attempts to conceive?
Select 2. (0 / 2 selected)
100%
AReplace valproic acid with topiramate PO
BDiscontinue valproic acid PO without replacement
CReplace minocycline with isotretinoin PO
DReplace valproic acid with carbamazepine PO
EReplace minocycline with doxycycline PO
FReplace valproic acid with levetiracetam PO
GDiscontinue minocycline PO
HReplace valproic acid with phenytoin PO
IContinue valproic acid PO at the lowest effective dose
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