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Mixed Practice 52

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Case 1 of 9Pregnancy and Reproductive HealthInfertility (e.g., polycystic ovarian syndrome)

A 34-year-old man and his 33-year-old partner have been unable to conceive after 18 months of regular unprotected intercourse. His partner's fertility assessment is normal. He is a competitive powerlifter who used stanozolol and injectable testosterone for 6 years and stopped all anabolic-androgenic steroids 8 months ago; abstinence is confirmed. He has no other medical conditions and takes no medications. On examination, both testes are small at 12 mL each (15-25) and soft, with no varicocele. Semen analysis shows a sperm concentration of 1.2 million/mL (at least 16) on two occasions. Luteinizing hormone is 2.1 IU/L (1.7-8.6), follicle-stimulating hormone 1.9 IU/L (1.5-12.4), and total testosterone 8.0 nmol/L (9.9-27.8).

Heart rate64/min
Respiratory rate14/min
Temperature36.8 °C
O2 saturation99%, room air
Blood pressure128/78 mm Hg

Question 1 of 28

Given the patient's persistent steroid-induced suppression of spermatogenesis, which of the following are the most appropriate medication options to promote recovery of sperm production?

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