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Gynecologic — Vulvar pruritus

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Case 1 of 5GynecologicVulvar pruritus (e.g., lichen sclerosus)

A 29-year-old woman presents with a 10-day history of thin vaginal discharge with a fishy odour that is worse after intercourse, along with mild vulvar irritation. She has a single long-term partner, uses a combined oral contraceptive, takes no other medications, and has no known drug allergies. Urine hCG is negative. On speculum examination there is a thin, homogeneous, grey-white discharge coating the vaginal walls, with no vaginal or cervical inflammation. Vaginal pH is 5.5 (3.8-4.5), the whiff test is positive, and wet mount shows clue cells with no hyphae or motile trichomonads. Treatment is indicated.

Heart rate72/min
Respiratory rate14/min
Temperature36.8 °C
O2 saturation99%, room air
Blood pressure112/70 mm Hg

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Which of the following are the most appropriate treatment options?

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