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Gynecologic — Menopause-related symptoms

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Case 1 of 7GynecologicMenopause-related symptoms (e.g., hot flashes, sleep disturbance)

A 56-year-old woman comes to the clinic because of bothersome hot flashes. She has about 10 hot flashes a day, and night sweats wake her several nights a week. Her last menstrual period was at age 51. Two years ago she had a lumpectomy and radiation for an estrogen receptor-positive breast cancer, and she has taken tamoxifen 20 mg PO daily since then; her oncologist plans to continue it for 5 years. She has no history of depression, and she has no known drug allergies. She asks whether she can take the "hormones" her friend uses for hot flashes. Examination is unremarkable.

Heart rate76/min
Respiratory rate14/min
Temperature36.8 °C
O2 saturation98%, room air
Blood pressure124/78 mm Hg

Question 1 of 21

Which one of the following is the most appropriate first-line pharmacologic therapy for this patient's hot flashes?

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