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Gastrointestinal and Hepatic — Dysphagia

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Case 1 of 1Gastrointestinal and HepaticDysphagia (e.g., esophagitis, esophageal cancer)

A 48-year-old man presents to the family practice clinic with an 8-month history of progressive difficulty swallowing both solids and liquids. He regurgitates undigested food, sometimes at night, and has lost 5 kg over this time. He has no heartburn, takes no medications and has no known allergies. There is no family history of gastrointestinal cancer. Examination is unremarkable. Hemoglobin is 138 g/L (135-175). A barium swallow shows a dilated esophagus that tapers smoothly to a bird's-beak narrowing at the gastroesophageal junction.

Heart rate72/min
Respiratory rate14/min
Temperature36.8 °C
O2 saturation98%, room air
Blood pressure124/78 mm Hg

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Which one of the following is the most appropriate next investigation?

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