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Endocrine and Metabolic — Adrenal disease

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Case 1 of 1Endocrine and MetabolicAdrenal disease

A 55-year-old man is brought to the emergency department with 24 hours of vomiting, marked weakness, and light-headedness on standing. He has primary adrenal insufficiency due to autoimmune adrenalitis and takes hydrocortisone 20 mg PO in the morning, hydrocortisone 10 mg PO in the afternoon, and fludrocortisone 0.1 mg PO daily. He has vomited his tablets since yesterday, did not increase his steroid dose when the illness began, and has no injectable hydrocortisone at home. On examination he is ill-appearing with dry mucous membranes, and his abdomen is soft and mildly diffusely tender. His usual BP is 118/74 mm Hg. Sodium 127 mmol/L (135-145), potassium 5.8 mmol/L (3.5-5.0), creatinine 135 umol/L (60-110), and glucose 4.4 mmol/L (3.9-7.8).

Heart rate104/min
Respiratory rate20/min
Temperature38.2 °C
O2 saturation98%, room air
Blood pressure96/60 mm Hg

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Which of the following are the most appropriate initial treatments for this patient?

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